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Looking To Invest In Artificial Intelligence? Consider Evogene And Its Five Subsidiaries

TalkMarkets on EVGN

Evogene ( EVGN ) oversees five subsidiaries: Biomica, agPlenus, Lavie Bio, Castera, and Canonic. Each company uses Evogene’s unique artificial intelligence (AI) platform to develop products for different human medical needs and the agricultural industries. Their CPB platform, which stands for computational predictive biology, provides efficient ways to map plant phenotypes and microbial genomes. Their subsidiaries employ this AI technology to improve plant genetics, commercial fertilizers, and human medicines. Evogene produces revenue via its subsidiaries in two ways. It brings in benchmark and licensing payments from companies, who use its products and research. The main function of each subsidiary is to conduct research within their specialties using the CPB platform. The company also makes revenues from at-the-market sales of some of its products, including medical cannabis and wheat seed stimulant. Evogene’s stock price has been on the long-term downtrend which mirrors the trend of current market conditions. Global economic destabilization, ongoing bank crises, and historical interest rate hikes have diligently wrecked ideal market conditions for all stocks. These conditions may get worse and promise to stick around for a while. Buy ratings must be considered under these volatile conditions. Evogene has managed to stay afloat and its financial performance has continued to improve throughout this bearish period. Revenues are increasing for the company and each of its subsidiaries have new developments in their pipelines. The company’s stock price is trading at or near its all-time low and is undervalued at the moment. The situation may present an opportunity for investment with an eye to long-term growth. Updates on Evogene’s subsidiaries Lavie Bio uses Evogene’s MicroBoost AI engine to innovate agricultural supplements, like growth stimulates and fertilizer. The company recently received a $10 million investment from ICL (ICL) under a SAFE agreement. The company will collaborate with ICL to develop new agricultural products, here fertilizer. ICL is a global manufacturer of products made with specialty minerals. Lavie Bio currently has a growth stimulant on the market called Thrivus. Their spring wheat seed treatment, a microbiome-based bio-inoculant, was released on the market in the US during 2022 and sold out initially. The product increases summer wheat yields by up to four bushels per acre. The company plans to expand sales of Thrivus to other countries, like Canada and Europe. Lavie Bio also has a bio-fungicide, up for approval by the US EPA, which fights fruit rot and powdery mildew. It hopes to bring the fungicide to market in 2024 with focus on treating grape harvests. Biomica uses Evogene’s MicroBoose AI to develop microbiome-based medical treatments. The company currently has three drug candidates, which are undergoing clinical research and trials. BMC-128 is being developed to treat solid tumors in humans. The drug candidate is currently being tested on cancer patients in a Phase 1 clinical trial for human safety. The company hopes to begin Phase 1b/2 in 2024. The company’s second drug candidate, BMC333, is a microbiome therapeutic for treating inflammatory bowel disease. The drug, consisting of a combination of four live bacteria strains, has been tested on animals and found to reduce inflammation and tissue damage along the GI tract. The company plans a phase 1 trial in 2024. Biomica’s third drug candidate, BMC426, is being considered for the treatment of irritable bowel syndrome. The company has completed discovery with its candidate and has moved into pre-clinical trials. Biomica recently received a $20 million investment round led by Shanghai Healthcare Capital. The deal received regulatory approval from China today and allows for future investment rounds. AgPlenus uses Evogene’s ChemPass AI technology to develop commercial herbicides, insecticides, and fungicides. The company is currently focused on developing an herbicide which is effective on herbicide resistant weeds in commercial crops. AgPlenus’s current candidate, APH1, is an herbicide for treating unwanted weeds in large commercial grow operations. The company is in a partnership with Corteva ( CTVA ) for developing new herbicides. AgPlenus discovers new herbicide candidates, while Corteva tests them and ultimately licensing them. AgPlenus has other products under development, including a fungicide. Casterra, Evogene’s newest subsidiary, uses the company’s GeneRaptor AI technology to innovate novel castor plant varieties. Castor seeds processed into oil are used worldwide for bio-diesel and are currently in high demand. The company recently signed an agreement with a European energy company to provide castor seeds and technical support for a set of cultivation sights in Africa. Casterra has another agreement with Titan Castor Farms in Zambia for production and distribution of its castor seeds. The company feels that castor seeds may be the next major catalyst for its financial performance and shareholders. Canonic uses Evogene’s GeneRaptor AI technology to map and breed cannabis genetics for medical applications. The cannabis strains are bred to have specific traits for treating certain medical conditions. The company has recently released its second-generation cannabis products in the Israeli medical cannabis market. These new genetics were perfected at Canonic’s cannabis research facility and boast a high THC potency of 24%. The products consist of a selection of dried flowers and THC oil tinctures. Evogene’s financial performance Over the last four quarters, revenues have increased for Evogene. In their Q3-2022 filings, the company reported revenues of $466K showing a more than 200% increase YoY. In their recent Q4-2022 filings, the company reported revenues of $660K more than 100% increase YoY and a 40% increase from last quarter. The company also reported its 2022 fiscal year performance. Revenue increased more than 80% from $930K (2021) to 1.675 million (2022). Evogene receives revenues through benchmark and licensing payments from companies usings its products and research. The company also has revenues from medical cannabis sales by Canonic and from sales of Lavio Bio’s wheat stimulant. The company expects future revenues from Casterra and its recent agreements to supply castor seed and support. The market consensus for Q1-2023 revenue estimates is $2 million, a significant increase from previous quarters. Whether or not the company hits that estimate, its revenues should continue to grow from quarter to quarter. Evogene reported a net loss of $3.8 million for Q4-2022, which is less than previous quarters. The company has a cash position of $31.860 million and receives enough money in receivables to continue its business and research strategy for some time. Evogene is set to receive $3.5 million from Bayer ( BAYRY ) for their seed trait collaboration agreement. The company’s largest operational cost is funding research and development. The company has no bank debt. The company requires about $4 million per quarter to operate. Evogene competes with such companies as Schödinger ( SDGR ), Ginkgo Networks ( DNA ), Exscientia ( EXAI ), and Relay Therapeutics ( RLAY ). Evogene is currently undervalued Evogene’s stock price has been trading under a $1 per share since September 2022. In January, the price began an uptrend towards a dollar per share, but in February a new down trend emerged. The price now sits near its all-time low around $.63 per share. There is a possibility that the company’s stock will have to undergo a reverse split to meet the minimum price requirements of $1 per share. So long as the stock price is low, the company remains undervalued. Its stock is currently trading at.49x NTM Total Enterprise Value / Revenue. The situation may present an opportunity to begin a long-term investment in the company’s stock. Evogene’s financials are sound and its research and product pipelines are robust. Greater market volatility may be the largest barrier in giving the company a strong buy rating for the time being. Conclusion Keep your eye on Evogene’s financial performance and research developments from its five subsidiaries. The company has been perfecting AI technology for a long time and its applications have produced innovative products. The company will continue to raise revenue numbers with its at the market products and benchmarks payments. Evogene has plenty of incoming receivables to fuel its research agenda and business strategy. The company’s stock is at an all-time low, while the company’s financial performance is on par with expectations. The metrics show that the company is currently undervalued and an investment opportunity may soon present itself. Larger market conditions will help decide if a long-term investment is tenable. Originally published at TalkMarkets. Related Articles: Biomica Announces Closing Of $20 Million Financing Round Led By Shanghai Healthcare Capital Evogene Offers An Excellent Risk/Reward Ratio More By This Author: Up In Smoke: Cannabis In A Bear Market Disclosure: This article is part of a new “UnderCovered” series of exclusive articles featuring companies with limited coverage. Authors are compensated by TalkMarkets for their time, and otherwise represent their own assessments and opinions. Authors are not compensated by the subject companies in any way. This article is also part of our IR Insights Initiative in which articles about participating companies can receive greater visibility. To learn more click here. Author Disclosure: No position in EVGN at the time of writing. Contact Details TalkMarkets ir@talkmarkets.com

April 28, 2023 09:00 AM Eastern Daylight Time

Synairgen CEO lays out plans for 2023 and beyond

Synairgen PLC

Synairgen PLC (AIM:SNG, OTC:SYGGF) chief executive Richard Marsden talks to Proactive following the release of full year results for calendar year 2022 - a year he says was "quite challenging at times." Marsden discusses the UK-based respiratory company's clinical development plan to take the SNG001 drug through Phase 3 trials and registration. The drug is being developed to help patients with respiratory viruses such as influenza virus, RSV, and SARS- CoV-2. The plan was formulated after a year of data collection and consultation with experts. He also highlights the company's relatively strong cash position, which he says will "allow [Synairgen] to get on with" its planned work schedule. Contact Details Proactive UK Ltd Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

April 28, 2023 03:00 AM Eastern Daylight Time

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C4X Discovery Holdings making "slight pivot" to anti-inflammatory treatments

C4X Discovery Holdings PLC

C4X Discovery Holdings PLC (AIM:C4XD) CEO Clive Dix speaks to Thomas Warner from Proactive after releasing half-year results for the six months ending 31 January 2023. Dix gives his highlights from the interim results before turning his focus to what he describes as a "slight pivot" to anti-inflammatory treatments. C4X has a portfolio of anti-inflammatory targets, including a molecule for COPD, and four or five new anti-inflammatory targets in the pipeline, which will be revealed in due course. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

April 28, 2023 03:00 AM Eastern Daylight Time

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Creo Medical Group FY22 results and recent funding - Proactive Research Analyst

Creo Medical Group PLC

Proactive Research Analyst John Savin gives the highlights from his latest research note on UK-based medical device company Creo Medical Group PLC (AIM:CREO). Savin talks about the company's recent performance and key products, before moving on to look at how it is positioned for the future. He also touches on a recent placing that generated a net £32 million. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

April 28, 2023 03:00 AM Eastern Daylight Time

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ImmuPharma "looking forward" to upcoming FDA meetings

ImmuPharma PLC

ImmuPharma PLC (AIM:IMM, OTC:IMMPF) chief executive Tim McCarthy spoke to Thomas Warner at Proactive's London studio, following what he calls a "very busy time" for the specialty biopharmaceutical company. He discusses the latest developments and next steps for the P140 platform, highlighting the importance of two upcoming meetings with the US FDA. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

April 28, 2023 03:00 AM Eastern Daylight Time

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Maureen McBride Named CEO of UNOS

United Network for Organ Sharing

Maureen McBride, Ph.D., has been named CEO of United Network for Organ Sharing (UNOS), the mission-driven, non-profit organization that serves as the nation’s organ donation and transplant system — the Organ Procurement and Transplantation Network (OPTN) — under contract with the federal government. “We conducted an exhaustive nationwide search for a new CEO and were pleased to find that the most qualified candidate is Dr. McBride,” said UNOS Board President Jerry McCauley, M.D., who chaired the Search Committee. “She impressed the Committee with her innovative spirit, clear-eyed vision of transformational change at UNOS and knowledge of the challenges facing the organ donation and transplantation community today. Since taking over as Interim CEO seven months ago, Dr. McBride has shown that she embodies a much-needed change in approach and operations at UNOS. She has put the organization on a new trajectory by increasing transparency and communication with the organ donation and transplantation community, regulators, Congress and the public, and advancing new initiatives to modernize and improve the organ donation and transplant system to benefit patients and ensure public trust.” Under McBride’s leadership, UNOS released an Action Agenda earlier this year, a comprehensive set of improvements in critical areas of the transplant system, including transparency, accountability, equity, transportation and modernization. McBride has worked for UNOS since 1995. She has served as Interim CEO since October 2022 and before that, as Chief Operating Officer managing the OPTN contract. She was also the organization’s Director of Research from 2006 to 2014 and contributed to more than 50 research manuscripts and publications. As CEO, she directs the efforts of 450 UNOS staff to ensure that the nation’s organ donation and transplant network efficiently and fairly serves the needs of transplant candidates and recipients, living donors and donor family members, and professionals in the field. She will be the first woman to lead the organization. “I am humbled, thrilled and energized to be selected to serve as CEO of UNOS,” McBride said. “As long as there are patients in desperate need of organs, we have more work ahead of us. As we move forward in our mission to save more lives, I look forward to leading UNOS during a time of immense change. As I said in my first official remarks as Interim CEO: we can do better, we must do better, and we will do better. We are excited to show our ongoing commitment to saving lives, how we are best situated to help usher in proposed improvements and how our expertise should remain an integral part of the system. Additionally, I am excited to continue working with UNOS’ other non-OPTN business lines to enhance and grow our organization.” In selecting McBride, the UNOS Corporate Affairs Committee agreed this is a pivotal moment in the organization’s history. They cited her leadership skills and proven ability to navigate organizational change both internally and externally as the lifesaving work continues and as UNOS prepares to respond to the federal government’s upcoming RFPs for the new OPTN contract. This includes her institutional knowledge of UNOS and the entire organ donation and transplant community; her experience in the field; her commitment to clear and frequent communication to build trust, understanding and consensus; and her unquestioned commitment to the organization and its mission to save as many lives as possible through organ donation and transplantation. She received her bachelor of science in mathematics from Loyola College in Maryland and her Ph.D. in biostatistics from Virginia Commonwealth University, Medical College of Virginia. McBride has served as the Executive Director of the OPTN since October 2022. She will begin her new role with UNOS immediately. About UNOS United Network for Organ Sharing (UNOS) is the mission-driven non-profit serving as the nation’s transplant system under contract with the federal government. We lead the network of transplant hospitals, organ procurement organizations, and thousands of volunteers who are dedicated to honoring the gifts of life entrusted to us and to making lifesaving transplants possible for patients in need. Working together, we leverage data and advances in science and technology to continuously strengthen the system, increase the number of organs recovered and the number of transplants performed, and ensure patients across the nation have equitable access to transplant. Contact Details United Network for Organ Sharing Anne Paschke +1 804-782-4730 anne.paschke@unos.org Company Website https://unos.org

April 27, 2023 02:36 PM Eastern Daylight Time

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News Release

NuGen Medical Devices begins feasibility study in the Netherlands for InsuJet and Ozempic

NuGen Medical Devices

NuGen Medical Devices executive chairman Tony Di Benedetto joined Steve Darling from Proactive to provide details about the company that is developing the next generation of needle-free technologies for both humans and animals. Di Benedetto shares with Proactive more about the technology behind products InsuJet and PetJet and also about an assessment and feasibility study in the Netherlands of InsuJet for Semaglutide or its more widely known name Ozempic. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

April 27, 2023 01:36 PM Eastern Daylight Time

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USDA’s ‘Defend the Flock’ Campaign Addresses How to Help Keep Your Backyard Chickens Safe from Bird Flu

YourUpdateTV

Over the last several years, more people have turned to raising chickens at home. But a highly infectious bird flu called Highly Pathogenic Avian Influenza (HPAI) has created challenges for backyard growers, already affecting more than 58 million birds nationwide. Recently, Dr. Julie Gauthier, the Assistant Director of Poultry Health at the U.S. Department of Agriculture, participated in a nationwide satellite media tour to discuss the crisis and how their ‘Defend the Flock’ campaign is helping address the issue. A video accompanying this announcement is available at: https://youtu.be/-7Wg4IcF5Bc The U.S. poultry industry is one of the largest in the world and an important sector of our agricultural economy. Disease outbreaks can devastate flocks, impact trade, cause job and financial losses, and affect prices on eggs, prepared poultry, and other staples. The Defend the Flock education program offers free tools and resources to help everyone who handles or works with poultry follow proper biosecurity practices. These practices will help keep your birds healthy and reduce the risk of avian influenza and other infectious diseases. Tips include: · Keep flocks away from open water and wild birds that can carry disease · Separating your poultry from the rest of your property, using only one entry and exit point · Clean regularly and wear dedicated clothes and shoes when tending to your flock · Clean equipment and vehicles with soap and water before and after they are near your flock · Don’t share tools, poultry supplies or equipment with other flock owners · Report sick birds and know the warning signs, including lower egg production, soft-shelled or misshapen eggs, and runny nose, sneezing and trouble breathing. Report any signs of illness or unexplained deaths to your veterinarian, animal health official, or call the USDA at 866-536-7593 For more tips and advice to keep your chickens safe, search online for ‘Defend the Flock’ About Dr. Julie Gauthier Dr. Julie Gauthier is Assistant Director for Poultry Health and a Veterinary Medical Officer at the U.S. Department of Agriculture/APHIS. The doctor is a Veterinary Medicine Prevention Officer for the U.S. Army Reserve where she has served for more than five years. Dr. Gauthier received her Master’s in Public Health from the Yale School of Public Health and her Doctorate in Veterinary Medicine from Michigan State University. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

April 27, 2023 10:31 AM Eastern Daylight Time

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RemSleep Holdings Inc. Provides Shareholder Update

RemSleep Holdings, Inc.

RemSleep Holdings Inc. (OTCQB: RMSL), a medical device manufacturer dedicated to forever changing the level of treatment provided to Obstructive Sleep Apnea (OSA) patients, provides an update on its testing protocol for 510K clearance of its DeltaWave CPAP Mask as well as positive developments for its next generation masks which have shown internal indications of relief from those suffering with certain comorbidities in conjunction with their sleep apnea. The company previously announced DeltaWave testing was targeted to be completed in 14-18 weeks prior to submission for 510K clearance. The original timeline put the target towards mid to end of March of this year. After further review and discussion with the company’s partnering lab and our compliance director, the timeline has been extended 7-8 weeks. One of the lengthier tests in the protocol (Cytotoxicity) had been restarted roughly halfway through the testing process due to a contaminated sample. The source of contamination could not be identified but it was determined to not come from the mask itself. Out of caution for any impact on the final results, the test was halted, and a new test started with a sealed DeltaWave sample from the original sample batch provided to the testing lab. The current test is on track to be completed towards the middle to end of May as previously announced on the company Twitter feed. It is important to note that there was no product failure in the test; rather, it was procedurally driven due to an observation of contamination once the test had already begun. While these issues cannot be foreseen and every step is taken to prevent them, it is also standard practice to provide additional, sealed samples for testing in an event such as this. While the delay was unexpected and frustrating, preparing for the possibility ahead of time resulted in the delay being relatively minimal. The company recently announced a new test is being run in addition to those in the original protocol. The additional test was deemed prudent due to the ongoing recalls and scrutiny in the CPAP industry and to alleviate any potential concerns going forward based on these ongoing changes. However, due to the lengthier Cytotoxicity test being restarted, the additional test will have no impact on the May timeframe. To date, all completed tests have provided the results as expected and the company remains confident the remaining tests will show similar results. Once these tests have ended, the company expects it will take 3-6 weeks for Risk Management Assessments to be completed, 3rd party certification of toxicology results, and final compilation to submit to the FDA for 510K clearance. The company has just recently received positive news on their next generation DeltaWave masks with respect to design and performance. RemSleep believes this provides significant support to the design being unique for respiratory masks and ultimately what the company considers to be the pathway for relief for those aforementioned sufferers. The company continues to evaluate medical centers & sleep study centers to perform the tests & trials demonstrating that relief from a clinical standpoint. RemSleep believes the potential for these masks to compete in the institutional and residential spaces will position the company in a much better position strategically and financially over the DeltaWave alone. As the company previously discussed in the shareholder letter at the beginning of the year, CPAP device sales continue to be a focus. While RemSleep had several promising commitments early on that started the initiative and fell through, the last several months have shown several new sales channels opening up with orders being taken. While equipment sales are important for revenue and cash flow, ultimately the company is looking at sales of these devices to establish new sales channels and relationships to partner with once the DeltaWave line of masks are cleared. RemSleep CEO, Tom Wood, commented further: “Obviously the stopping and restarting of a critical test is frustrating as a CEO, shareholder, and a product designer. The regulatory landscape has changed dramatically since the last product I brought to market and the increased scrutiny of respiratory devices and masks in general certainly isn’t making it any easier. While frustrating, it also reaffirms the decision we made to hire Ms. Strzepek with her specific, regulatory experience with respiratory masks, to oversee the 510K process. She remains invaluable to navigating this fluid environment and addressing any issues ahead of time that could be cause for concern on the administrative and procedural processes. Despite these challenges, I have never been more confident or excited for the impact I believe RemSleep can have on the market with the DeltaWave as well as the next generation devices as we near the end of the testing process. It can be a difficult balance trying to share that confidence and excitement while dealing with the day-to-day issues, delays, and waiting but I hope that passion we must make these products successful continues to be seen and understood by our shareholders.” The company will continue to update investors as information becomes available and is confirmed. RemSleep appreciates the ongoing questions and interest in the DeltaWave products and will follow up accordingly in press releases, on the company website: www.remsleep.com, and through the company Twitter feed: @RemsleepInc About RemSleep Holdings Inc. RemSleep Holdings Inc. is a medical device manufacturer dedicated to forever changing the level of treatment provided to obstructive Sleep Apnea patients. Our focus is primarily designing and manufacturing devices and products for the treatment of Sleep Apnea and other respiratory conditions. With over 30 years of collective experience in CPAP therapy, the RemSleep team has extensive knowledge and understanding of CPAP and the challenges of patient compliance. We diligently strive for our products to make a difference and improve the condition of those suffering from Sleep Apnea. www.remsleep.com https://twitter.com/RemsleepInc Forward-Looking Statements Some statements in this release may contain forward-looking information. All statements, other than of historical fact, that address activities, events or developments that the Company believes, expects or anticipates will or may occur in the future (including, without limitation, statements regarding potential acquisitions and financings) are forward-looking statements. Forward-looking statements are generally identifiable by use of the words "may", "will", "should", "continue", "expect", "anticipate", "estimate", "believe", "intend", "plan" or "project" or the negative of these words or other variations on these words or comparable terminology. Forward-looking statements are subject to a number of risks and uncertainties, many of which are beyond the Company's ability to control or predict, that may cause the actual results of the Company to differ materially from those discussed in the forward-looking statements. Factors that could cause actual results or events to differ materially from current expectations include, among other things, without limitation, the inability of the Company to obtain sufficient financing to execute the Company's business plan; competition; regulation and anticipated and unanticipated costs and delays, and other risks disclosed in the Company's public disclosure record on file with the relevant securities regulatory authorities. No information in this press release should be construed as any indication whatsoever of the Company's future revenues, results of operations or stock price. Although the Company has attempted to identify important factors that could cause actual results or events to differ materially from those described in forward-looking statements, there may be other factors that cause results or events not to be as anticipated, estimated or intended. Readers should not place undue reliance on forward-looking statements. The forward-looking statements included in this news release are made as of the date of this news release and the Company does not undertake an obligation to publicly update such forward-looking statements to reflect new information, subsequent events or otherwise unless required by applicable securities legislation. Investor Relations Contact: Preya Narain info@preya.co Contact Details Preya Narain, Investor Relations info@preya.co Company Website https://remsleep.com/

April 26, 2023 11:44 AM Eastern Daylight Time